Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in
physiological and different pathophysiological conditions. Ischemic stroke has a complex …

Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood
vessels. Two main aims in acute stroke therapy include the restoration of cerebral blood flow …

Background Ischemic stroke is the combinatorial effect of many pathological processes
including the loss of energy supplies, excessive intracellular calcium accumulation …

Previous studies in our laboratory have shown that nicotine exposure decreases glucose
transport across the blood–brain barrier in ischemia‐reperfusion conditions. We hypothesize …

Women continue to face a greater lifetime morbidity and mortality from stroke and have been
shown to respond differently to stroke treatments compared to men. Since 2016, updated …

Stroke is one of the leading causes of death and disability worldwide. Brain injury after
ischemic stroke involves multiple pathophysiological mechanisms, such as oxidative stress …

Background: Stroke in context of type 2 diabetes (T2D) is associated with a poorer outcome
than in non-diabetic conditions. We aimed at creating a new reproducible mouse model of …

Diabetes mellitus is a disease of abnormal carbohydrate metabolism characterized by
hyperglycemia. It is associated with a relative or absolute impairment in insulin secretion …

Diabetes is considered a major risk factor for stroke and is associated with worsened stroke
outcomes. Here, we discuss and summarize the mechanisms that have been associated …

Smoking-derived nicotine (N) and oral contraceptives (OC) synergistically exacerbate
ischemic brain damage in the females and underlying mechanisms remain elusive. Our …