In general, the effectiveness of radiation treatment is evaluated through the observation of
morphological changes with computed tomography (CT) or magnetic resonance imaging …

Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical
research that aims to perform noninvasive detection of tissue metabolism in disease states …

Free radicals, such as metabolic intermediates, reactive oxygen species, and metal
enzymes, are key substances in organisms, although they can also cause various oxidative …

Melanin is a pigment that includes free radicals and is widely distributed in living animals.
Malignant melanoma is one of the most progressive tumors in humans with increasing …

In vivo decay rates of a nitroxyl contrast agent were estimated by a MR redox imaging
(MRRI) technique and compared with the decay rates obtained by the electron …

Tissue redox metabolism is involved in various diseases, and an understanding of the spatio-
temporal dynamics of tissue redox metabolism could be useful for diagnosis of progression …

Understanding the tumor redox status is important for efficient cancer treatment. Here, we
noninvasively detected changes in the redox environment of tumors before and after cancer …

Redox reactions that generate free radical intermediates are essential to metabolic
processes, and their intermediates can produce reactive oxygen species, which may …

The experience in free radical biology and medicine shows the crucial role of redox
signalling in carcinogenesis. The cells and tissues of healthy mammals are characterised by …

Developing imaging biomarkers for non-invasive measurement of the tissue redox state is a
key research area. Recently, we presented the first non-invasive MR imaging method that …