The DNA of all living organisms is persistently damaged by endogenous reactions including
deamination and oxidation. Such damage, if not repaired correctly, can result in mutations …

DNA methylation is an epigenetic mark that regulates gene expression in mammals. One
method of methylation removal is through ten–eleven translocation–catalyzed oxidation and …

Cytotoxic and mutagenic methylated bases in DNA can be generated by endogenous and
environmental alkylating agents. Such damaged bases are removed by three distinct …

The integrity of the genetic information is continuously challenged by numerous genotoxic
insults, most frequently in the form of oxidation, alkylation or deamination of the bases that …

Emerging data suggest an important role for cytosine methylation in tumorigenesis.
Simultaneously, recent studies indicate a significant contribution of endogenous oxidative …

Methylation of cytosine at the C5 position (5mC) represents an epigenetic modification that
plays a fundamental role in embryonic development, transcriptional regulation, and other …

In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T
and C, except for minor DNA base modifications such as methylation which serves for …

Chemically modified nucleic acid bases are sources of genomic instability and mutations but
may also regulate gene expression as epigenetic or epitranscriptomic modifications …

DNA base excision repair is essential for maintaining genomic integrity and for active DNA
demethylation, a central element of epigenetic regulation. A key player is thymine DNA …

Chemically modified bases exist naturally in genomic DNA. Research into these bases has
been invigorated by the discovery of several modified bases in the mammalian genome, in …