The use of intra-operative blood salvage, dialysis, and artificial organs are associated with
the application of non-physiological mechanical stress on red blood cells (RBCs). To …

Introduction: Accumulating evidence demonstrates that subhaemolytic mechanical stresses,
typical of circulatory support, induce physical and biochemical changes to red blood cells. It …

Introduction: Blood banking procedures are associated with damage to blood units, stored
as packed red blood cell (PRBC), which can affect the transfusion outcome. Specifically …

Background Donated blood is stored in the blood bank as packed red blood cell units. In the
process of packed cells preparation, the red blood cells (RBCs) are subjectedto high level of …

The supra‐physiological shear stress that blood is exposed to while traversing mechanical
circulatory assist devices affects the physical properties of red blood cells (RBCs), impairs …

Mechanical circulatory support device (MCS) design has improved over the years and yet
blood damage (eg, hemolysis) remains a problem. Accumulating evidence indicates a …

Red blood cells (RBCs) deformability refers to the cells' ability to adapt their shape to the
dynamically changing flow conditions so as to minimize their resistance to flow. The high red …

Simple Summary Deformation of red blood cells (RBCs) is essential in order to pass through
the smallest blood vessels. This cell function is impaired in the presence of high levels of …

Patients receiving mechanical circulatory support often present with heightened
inflammation and free radical production associated with pre‐existing conditions in addition …

Clinical experience with circulatory support devices has typically shown alteration of patient
blood rheology exhibited through increasing blood viscosity and decreasing erythrocyte …