Spinal 5-HT2A receptor is involved in electroacupuncture inhibition of chronic pain

XC Yuan, YY Wang, LX Tian, XJ Yan, YX Guo… - Molecular …, 2022 - journals.sagepub.com
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, and it is a typical
disease which can develop chronic pain. Our previous study has proved that …

[HTML][HTML] 5-HT7 Receptor Is Involved in Electroacupuncture Inhibition of Chronic Pain in the Spinal Cord

XC Yuan, XJ Yan, LX Tian, YX Guo, YL Zhao… - Frontiers in …, 2021 - frontiersin.org
Knee osteoarthritis (KOA) is a common and disabling condition characterized by attacks of
pain around the joints, and it is a typical disease that develops chronic pain. Previous …

Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model

Y Zhang, A Li, J Xin, L Lao, K Ren, BM Berman… - Neurochemical …, 2011 - Springer
We previously showed that electroacupuncture (EA) activates medulla-spinal serotonin-
containing neurons. The present study investigated the effects of intrathecal 5, 7 …

[HTML][HTML] Ea participates in pain transition through regulating KCC2 expression by BDNF-TrkB in the spinal cord dorsal horn of male rats

M Shi, J Zhou, R Hu, H Xu, Y Chen, X Wu, B Chen… - Neurobiology of Pain, 2023 - Elsevier
The pathogenesis of chronic pain is complex and poorly treated, seriously affecting the
quality of life of patients. Electroacupuncture (EA) relieves pain by preventing the transition …

Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain

Y Li, Z Fang, N Gu, F Bai, Y Ma, H Dong… - Journal of pain …, 2019 - Taylor & Francis
Purpose Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play
crucial roles in pain processing. Electroacupuncture (EA) is recognized as an alternative …

[HTML][HTML] Electroacupuncture regulates pain transition through inhibiting PKCε and TRPV1 expression in dorsal root ganglion

J Fang, S Wang, J Zhou, X Shao, H Sun… - Frontiers in …, 2021 - frontiersin.org
Many cases of acute pain can be resolved with few side effects. However, some cases of
acute pain may persist beyond the time required for tissue injury recovery and transit to …

[HTML][HTML] Electroacupuncture potentiates cannabinoid receptor-mediated descending inhibitory control in a mouse model of knee osteoarthritis

XC Yuan, B Zhu, XH Jing, LZ Xiong, CH Wu… - Frontiers in molecular …, 2018 - frontiersin.org
Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, which can lead to
chronic pain. Although electroacupuncture (EA) is effective in relieving chronic pain in the …

Downregulation of Spinal G Protein‐Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture

H Liu, SB Liu, Q Li, H Wang, YQ Wang… - Evidence‐Based …, 2015 - Wiley Online Library
Acupuncture or electroacupuncture (EA) has been demonstrated to have a powerful
antihypernociceptive effect on inflammatory pain. The attenuation of G protein‐coupled …

Electroacupuncture alleviates hyperalgesia by regulating CB1 receptor of spinal cord in incisional neck pain rats

J Wang, J Zhang, Y Gao, Y Chen… - Evidence‐Based …, 2021 - Wiley Online Library
Acupuncture therapy is effective in relieving postoperative pain of neck surgery, but its
underlying mechanisms remain largely unknown. This study, in the incisional neck pain rat …

Electroacupuncture alleviates chemotherapy‐induced pain through inhibiting phosphorylation of spinal CaMKII in rats

Y Zhang, A Li, J Xin, K Ren, BM Berman… - … Journal of Pain, 2018 - Wiley Online Library
Background Current medical treatments for chemotherapy‐induced pain (CIP) are either
ineffective or have adverse side effects. Acupuncture may alleviate CIP, but its effectiveness …