Background Psoriasis is a chronic, inflammatory cutaneous disease. FcγRIIB is a low-affinity
receptor for the IgG Fc fragment that provides a negative feedback pathway to down …

Keratinocytes of human epidermis are actively involved in inflammatory and autoimmune
reactions of the skin and interact with resident or infiltrating immunocompetent cells via …

Resveratrol, an anti-inflammatory agent, can inhibit pro-inflammatory mediators by activating
Sirt1, which is a class III histone deacetylase. However, whether resveratrol can regulate …

FcγRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in
controlling responses to infection, and reduced expression or function predisposes to …

Abstract Background Systemic sclerosis (SSc) is a systemic autoimmune disease
characterized by excessive fibrosis. FcγRIIB is a low-affinity receptor for the Fc fragment of …

Abstract FcγRIIb (CD32B, Online Mendelian Inheritance in Man 604590), an IgG FcR with a
tyrosine-based inhibitory motif, plays a critical role in the balance of tolerance and …

Immune inhibitory receptors play an important role in the maintenance of adequate
activation threshold of various cells in our immune system. The inhibitory Fc receptor, type …

Background In rheumatoid arthritis (RA) macrophages play a major role in amplifying
synovial inflammation. Important activating signals are those induced by Toll-like receptor …

Antibodies are secreted to recognize and in some cases directly neutralize pathogens.
Another important means by which they are essential components of the immune system is …

Abstract Background The inhibitory Fc receptor, FcγRIIB, has emerged as a key negative
regulator of B cell activation and as such is predicted to play an essential role in controlling …