Aims Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in
several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's …

The nuclear factor erythroid 2‐like 2 (NRF 2) is the master regulator of endogenous
antioxidant responses. Oxidative damage is a shared and early‐appearing feature in X …

Peroxisomal and mitochondrial malfunction, which are highly intertwined through redox
regulation, in combination with defective proteostasis, are hallmarks of the most prevalent …

The peroxisomal disease adrenoleukodystrophy (X-ALD) is caused by loss of the transporter
of very-long-chain fatty acids (VLCFAs), ABCD1. An excess of VLCFAs disrupts essential …

Abstract X-linked adrenoleukodystrophy (X-ALD) is the most frequent inherited monogenic
demyelinating disease (minimal incidence 1: 17,000). It is often lethal and currently lacks a …

Age-related decline in mitochondrial function and oxidative stress plays a critical role in
neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes …

Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects
have diverse metabolic consequences that could drive distinct pathophysiological states …

Mitochondrial impairment induced by oxidative stress is a main characteristic of intrinsic cell
death pathways in neurons underlying the pathology of neurodegenerative diseases …

A common process associated with oxidative stress and severe mitochondrial impairment is
the opening of the mitochondrial permeability transition pore, as described in many …

The receptor interacting protein-140 (RIP140) is a cofactor for several nuclear receptors and
has been involved in the regulation of metabolic and inflammatory genes. We hypothesize …