In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Abstract Development of the asymmetric amniotic sac—with the embryonic disc and
amniotic ectoderm occupying opposite poles—is a vital milestone during human embryo …

Gastrulation controls the emergence of cellular diversity and axis patterning in the early
embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the …

INTRODUCTION The period from peri-implantation to gastrulation is critical for mammalian
embryogenesis. During this time, connections between embryonic and maternal tissues are …

BACKGROUND Pluripotent cells are generated by embryonic divisions that occur shortly
after fertilization. These cells are transformed into the recognizable outline of an organism …

With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning. Despite its basic and clinical importance, early human …

Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …

The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent
stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …