A valence‐engineered self‐cascading antioxidant nanozyme for the therapy of inflammatory bowel disease

Q Wang, C Cheng, S Zhao, Q Liu, Y Zhang… - Angewandte …, 2022 - Wiley Online Library
Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly
effective disease treatment option. Nanozymes with multiple antioxidant activities can cope …

[HTML][HTML] ROS scavenging Mn 3 O 4 nanozymes for in vivo anti-inflammation

J Yao, Y Cheng, M Zhou, S Zhao, S Lin, X Wang… - Chemical …, 2018 - pubs.rsc.org
Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases,
including cardiovascular disease and cancer. Though highly efficient natural ROS …

A Redox Modulatory Mn3O4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

N Singh, MA Savanur, S Srivastava… - Angewandte …, 2017 - Wiley Online Library
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to
their therapeutic potential for the treatment of various diseases. Herein, we report that a …

Mn3O4 Nanozyme for Inflammatory Bowel Disease Therapy

Y Cheng, C Cheng, J Yao, Y Yu, Y Liu… - Advanced …, 2021 - Wiley Online Library
Recently, reactive oxygen species (ROS) scavenging nanozymes have been developed as
natural enzyme alternatives to treat inflammatory bowel disease (IBD) as well as other …

Self‐assembly of multi‐nanozymes to mimic an intracellular antioxidant defense system

Y Huang, Z Liu, C Liu, E Ju, Y Zhang… - Angewandte …, 2016 - Wiley Online Library
In this work, for the first time, we constructed a novel multi‐nanozymes cooperative platform
to mimic intracellular antioxidant enzyme‐based defense system. V2O5 nanowire served as …

A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system

N Singh, MA Savanur, S Srivastava, P D'Silva… - Nanoscale, 2019 - pubs.rsc.org
Biocompatible nanoparticles with an intrinsic ability to mimic the cellular antioxidant
enzymes are potential candidates for the development of new therapeutics for various …

Manganese‐Based Antioxidase‐Inspired Biocatalysts with Axial Mn−N5 Sites and 2D d‐π‐Conjugated Networks for Rescuing Stem Cell Fate

Z Wu, Y Sun, S Mu, M Bai, Q Li, T Ma… - Angewandte Chemie …, 2023 - Wiley Online Library
Constructing highly effective biocatalysts with controllable coordination geometry for
eliminating reactive oxygen species (ROS) to address the current bottlenecks in stem‐cell …

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Y Liu, Y Cheng, H Zhang, M Zhou, Y Yu, S Lin… - Science …, 2020 - science.org
Here, an integrated cascade nanozyme with a formulation of Pt@ PCN222-Mn is developed
to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide …

Construction of pH‐Dependent Nanozymes with Oxygen Vacancies as the High‐Efficient Reactive Oxygen Species Scavenger for Oral‐Administrated Anti …

N Zhao, FE Yang, CY Zhao, SW Lv… - Advanced …, 2021 - Wiley Online Library
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating
inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo2O4 …

Ligand‐dependent activity engineering of glutathione peroxidase‐mimicking MIL‐47 (V) metal–organic framework nanozyme for therapy

J Wu, Y Yu, Y Cheng, C Cheng, Y Zhang… - Angewandte …, 2021 - Wiley Online Library
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen
metabolic balance, yet limited GPx‐mimicking nanozymes are currently available for in vivo …