Disordered copper metabolism has been suggested to occur to several neurological
conditions, including Alzheimer's disease and Parkinson's disease. However, the underlying …

Impaired homeostasis of copper has been linked to different pathophysiological
mechanisms in neurodegenerative diseases and oxidative injury has been proposed as the …

It has been reported that disordered Cu metabolism is associated with several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Excessive copper can cause neurotoxicity and contribute to the development of some
neurological diseases; however, copper neurotoxicity and the potential mechanisms remain …

Background Being an essential trace element, copper is involved in diverse physiological
processes. However, excess levels might lead to adverse effects. Disrupted copper …

It has been widely reported that long-term exposure to copper increases the prevalence and
mortality of Parkinson's disease. Our previous study showed that CuSO 4 exposure induced …

Copper (Cu), one of the essential transition metal acts as a prosthetic group for variety of
proteins and metalloenzymes. However, it may be hazardous when administered in excess …

The epidemiological correlation between copper exposure and higher risk of Parkinson
disease (PD) has been recognized for a long time, and microglia-mediated …

Microglia-mediated neuroinflammation and the associated neuronal damage play critical
roles in the pathogenesis of neurodegenerative disorders. Evidence shows an elevated …

The prototype disease of Cu toxicity in human is Wilson disease, and cognitive impairment is
the presenting symptom of it. There is no study correlating Cu-induced excitotoxicity …