Purpose Total knee arthroplasty is associated with considerable perioperative hemorrhage.
The decrease in hemoglobin concentration and the need for allogenic blood transfusion are …

Objective: To compare the blood loss between intra-articular and intra-venous
administration of tranexamic acid (TXA) in patients undergoing primary total knee …

BACKGROUND Tranexamic acid decreases blood loss in primary total knee arthroplasty,
and no related prospective randomized clinical trials have been conducted to evaluate the …

Objective To evaluate the effectiveness and safety of a single intravenous dose of
tranexamic acid in order to reduce blood loss in total knee replacement. Materials and …

Tranexamic acid was intra-articularly injected in total knee arthroplasty (TKA) to reduce
blood loss and transfusion. However, no single study has been large enough to definitively …

Background: The most appropriate route of tranexamic acid administration is controversial.
In the current study, we compared the efficacy of intravenous (IV) and topical intra-articular …

Background Tranexamic acid (TXA) has shown significant reductions in blood loss and
transfusion rates in total knee arthroplasty (TKA). However, the optimal administration route …

Introduction Blood transfusion is often required in total knee replacement (TKR); several
methods of blood preservation are commonly used but the ideal solution is to reduce the …

Highlights•Tranexamic acid (TXA) can be administered via the intravenous (IV) and/or
topical (intra-articular, IA) route, which can possibly interrupt the cascade of events due to …

Background The optimal administration route of tranexamic acid (TXA) in total knee
arthroplasty (TKA), and the effect of TXA on hidden blood loss and total blood loss are …