Ciprofloxacin is a broad-spectrum antibiotic that targets bacterial topoisomerases, especially
DNA gyrase and topoisomerase IV. Ciprofloxacin has been commonly used until recently …

Ciprofloxacin is a widely used antibiotic since 1987 to treat a broad spectrum of bacterial
infections. Its main action is bactericidal. Adverse reactions are mild to moderate and include …

Fluoroquinolones are a class of widely prescribed antibiotics with a broad range of activity
against Gram-positive, Gram-negative, and some atypical microbes. Unfortunately, these …

The antibacterial activities of the fluorinated 4-quinolones (eg, ciprofloxacin) have been
ascribed to a marked inhibition of bacterial DNA gyrase. In contrast, the influence on purified …

An improved high-performance liquid chromatography (HPLC) procedure for the analysis of
ciprofloxacin and three of its metabolites in plasma, serum and urine samples was …

Fluoroquinolones (FQs) are a class of antibiotics with good oral bioavailability, making them
desirable treatment options for various bacterial infections, such as gastrointestinal, lower …

The authors proposed a simple, high throughput liquid chromatography-tandem mass
spectrometric (LC-MS/MS) method for the determination of ciprofloxacin in small sample …

Ciprofloxacin is an antibiotic that belongs to fluoroquinoles, characterized by broad
spectrum of action against pathogens, especially Gram (−) aerobic bacilli. For a long time, it …

The in vitro activity of LB20304 was evaluated against clinical isolates and compared with
those of Q-35, ciprofloxacin, sparfloxacin, lomefloxacin and ofloxacin. LB20304 …

Fluoroquinolones enter eukaryotic cells but the correlation between cellular accumulation
and activity remains poorly established. Gemifloxacin is known to accumulate to a larger …