To observe whether downhill running can lead to DNA damage in skeletal muscle cells and
changes in mitochondrial membrane permeability and to explore whether the DNA damage …

Eccentric exercise (EE) is known to induce damage and dysfunction in skeletal muscle.
However, the possible role of mitochondrial (dys) function, including the vulnerability to …

This study was undertaken to investigate the effect of exercise training on mitochondrial
DNA (mtDNA) oxidative damage and 8-oxoguanine DNA glycosylase-1 (OGG1) expression …

Purpose This study aimed to investigate the effects of downhill treadmill running on
mitochondrial structure/function and expression levels of mitophagy-related proteins in rat …

Key points• p53 is one of several important proteins that regulate the synthesis and function
of mitochondria in muscle, and mice lacking p53 have impaired aerobic capacity.• The role …

Purpose Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are associated
with metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM). Mitochondria …

AIM: Toinvestigatetheeffectofhypoxiacombinedwi…-tent, and the role of mitochondrial
biogenesis and mitophagy in this process. METHODS: Male Sprague-Dawley rats were …

The process of mitochondrial translation, in which mitochondrial (mt) DNA‐encoded genes
are translated into proteins, is crucial for mitochondrial function and biogenesis. In each …

Objective The aims of the present study were to determine in healthy animals if 1) acute
exercise stimulated traditional exercise signaling pathways in the cortex and striatum, and 2) …

Background: According to the theory of mitochondrial aging, oxidative stress plays a major
role in aging and age related degenerative diseases. Since oxygen consumption and …