Abstract Interferon regulatory factor 3 (IRF3)‐induced type I interferon (I‐IFN) production
plays key roles in both antiviral and autoimmune responses. IRF3 phosphorylation …

Transcription factors of IRF family, IRF-3, IRF-5 and IRF-7 play a critical role in the innate
antiviral response. In infected cells, IRF-3 and IRF-7 are activated by TBK-1 and IKKε …

Activation of the innate arm of the immune system following pathogen infection relies on the
recruitment of latent transcription factors involved in the induction of a subset of genes …

Interferon (IFN) regulatory factor 7 (IRF7) plays a key role in the production of IFN‐α in
response to viral infection, and phosphorylation at IRF7 C‐terminal serine sites is prelude to …

The transcription factor IRF3 is a central regulator of type I interferon (IFN) signaling. The
mechanisms underlying deactivation of IRF3 are poorly understood although many studies …

The transcription factor interferon regulatory factor 3 (IRF3) is essential for virus infection–
triggered induction of type I interferons (IFN-I) and innate immune responses. IRF3 activity is …

Abstract Interferon Regulatory Factor 3 (IRF3) is essential for the production of type I
interferon (IFN) during virus infection; however, the mechanism underlying its regulation …

IFN-β is a critical antiviral cytokine that is capable of modulating the systemic immune
response. The transcriptional induction of IFN-β is a highly regulated process, involving the …

Immunity to viruses requires an array of critical cellular proteins that include IFN regulatory
factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that …

Interferon (IFN) regulatory factors (IRF) are key transcription factors in cellular antiviral
responses. IRF7, a virus-inducible IRF, expressed primarily in myeloid cells, is required for …