Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …

The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the
passage of nutrients and molecules from the blood to the brain. This is critical for …

Growing evidence suggests that neurovascular dysfunction characterized by blood–brain
barrier (BBB) breakdown underlies the development of psychiatric disorders, such as major …

Major psychiatric disorders affect 25% of the population. While genetic and environmental
risk factors have been identified, the underlying pathophysiology of conditions, such as …

Several lines of evidence suggest that stress induces the neurovascular dysfunction
associated with increased blood–brain barrier (BBB) permeability, which could be an …

The blood-brain barrier (BBB) is composed of specific tight junction proteins and
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …

Depression and anxiety are comorbid conditions in many neurological or
psychopathological disorders. Stress is an underlying event that triggers development of …

The blood‐brain barrier (BBB) regulates the transport of micro‐and macromolecules
between the peripheral blood and the central nervous system (CNS) in order to maintain …

The blood–brain barrier (BBB) is an important physiologic barrier that separates CNS from
soluble inflammatory mediators and effector immune cells from peripheral circulation. The …

The mechanisms underlying the development and progression of psychiatric illnesses are
only partially known. Clinical data suggest blood‐brain barrier (BBB) breakdown and …