[HTML][HTML] The mouse metallomic landscape of aging and metabolism
Organic elements make up 99% of an organism but without the remaining inorganic
bioessential elements, termed the metallome, no life could be possible. The metallome is …
bioessential elements, termed the metallome, no life could be possible. The metallome is …
Systematic age‐, organ‐, and diet‐associated ionome remodeling and the development of ionomic aging clocks
Aging involves coordinated yet distinct changes in organs and systems throughout life,
including changes in essential trace elements. However, how aging affects tissue element …
including changes in essential trace elements. However, how aging affects tissue element …
Comparative genomics analysis of the metallomes
VN Gladyshev, Y Zhang - Metallomics and the Cell, 2013 - Springer
Biological trace metals are needed in small quantities, but used by all living organisms. They
are employed in key cellular functions in a variety of biological processes, resulting in the …
are employed in key cellular functions in a variety of biological processes, resulting in the …
Isotope metallomics approaches for medical research
Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and
perspectives from other “-omics” sciences (eg genomics, proteomics) and from research …
perspectives from other “-omics” sciences (eg genomics, proteomics) and from research …
Obesity and metabolomics: metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice
Obesity continues to rise as an alarming global epidemic. System level mechanisms,
diagnostics, and therapeutics are sorely needed so as to identify at risk individuals and …
diagnostics, and therapeutics are sorely needed so as to identify at risk individuals and …
[HTML][HTML] Metals in biology: from metallomics to trafficking
Nature relies on metals to facilitate an astounding variety of processes that are essential for
sustaining life. Metals are thought to play structural and chemical roles as cofactors of more …
sustaining life. Metals are thought to play structural and chemical roles as cofactors of more …
Baseline distribution of stable copper isotope compositions of the brain and other organs in mice
F Moynier, A Merland, D Rigoussen, J Moureau… - Metallomics, 2022 - academic.oup.com
Copper (Cu) stable isotopes are useful for understanding pathways and tracing changes in
Cu homeostasis, such as those induced by various diseases (eg liver cirrhosis, numerous …
Cu homeostasis, such as those induced by various diseases (eg liver cirrhosis, numerous …
Heterogeneous distribution of natural zinc isotopes in mice
Zinc (Zn) is required for the function of more than 300 enzymes involved in many metabolic
pathways, and is a vital micronutrient for living organisms. To investigate if Zn isotopes could …
pathways, and is a vital micronutrient for living organisms. To investigate if Zn isotopes could …
[HTML][HTML] Altered metal homeostasis associates with inflammation, oxidative stress, impaired glucose metabolism, and dyslipidemia in the crosstalk between childhood …
Á González-Domínguez, M Millán-Martínez… - Antioxidants, 2022 - mdpi.com
Metals are redox-active substances that participate in central biological processes and may
be involved in a multitude of pathogenic events. However, considering the inconsistencies …
be involved in a multitude of pathogenic events. However, considering the inconsistencies …
[HTML][HTML] Analytical methods for imaging metals in biology: from transition metal metabolism to transition metal signaling
Metal elements represent some of the most fundamental chemical building blocks of life and
are required to sustain the growth, development, and sustenance of all living organisms and …
are required to sustain the growth, development, and sustenance of all living organisms and …