Microbes rely on signal transduction systems to sense and respond to environmental
changes for survival and reproduction. It is generally known that niche adaptation plays an …

Two-component systems including histidine protein kinases represent the primary signal
transduction paradigm in prokaryotic organisms. To understand how these systems adapt to …

Global explorations of regulatory network dynamics, organization and evolution have
become tractable thanks to high-throughput sequencing and molecular measurement of …

Bacteria of many species rely on a simple molecule, the intracellular secondary messenger
c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice …

The prevalent paradigm governing bacterial two-component signaling systems (TCSs) is
specificity, wherein the histidine kinase (HK) of a TCS exclusively activates its cognate …

Chemosensory system is the most complex, specialized mode of signal transduction in
bacteria and archaea. It is composed of several core and auxiliary protein components that …

Bacteria contain a large variety of signal transduction systems that sense signals either in
the cytosol or in the extracytosolic space, and mediate a variety of responses, for example …

Synthetic biology aims to apply engineering principles for the rational, systematical design
and construction of biological systems displaying functions that do not exist in nature or even …

The evolution of macromolecular complex is a fundamental biological question, which is
related to the origin of life and also guides our practice in synthetic biology. The …

Understanding the principles underlying the plasticity of signal transduction networks is
fundamental to decipher the functioning of living cells. In Myxococcus xanthus, a particular …