Fatty acid uptake is essential for cell physiological function, but detailed mechanisms remain
unclear. Here, we generated an acetyl-CoA carboxylases (ACC1/2) double-knockout cell …

Despite scientific development, cancer is still a fatal disease. The development of cancer is
thought to be significantly influenced by fatty acids. Several mechanisms that control fatty …

To proliferate, metastasize, or resist stress conditions imposed by the microenvironment,
many cancer cells rely on fatty acid β-oxidation to generate acetyl-CoA and fuel the TCA …

Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Despite the remarkable clinical success of immunotherapy and molecular targeted therapy
in patients with advanced tumors, chemotherapy remains the most commonly used …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

The fatty acid transport proteins (FATP) are classified as members of the solute carrier 27
(Slc27) family of proteins based on their ability to function in the transport of exogenous fatty …

Chemotherapy is one of the primary treatments for most human cancers. Despite great
progress in cancer therapeutics, chemotherapy continues to be important for improving the …

Obesity has been associated with increased incidence and mortality of a wide variety of
human cancers including colorectal cancer. However, the molecular mechanism by which …

The importance of fatty acid (FA) metabolism in cancer is well-established, yet the
mechanisms underlying metabolic reprogramming remain elusive. Here, we identify …