Philadelphia-negative myeloproliferative neoplasms (MPNs) regroup hematological
malignancies arising from the clonal expansion of a hematopoietic stem cell (HSC) and lead …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by the clonal
expansion of myeloid cells, notably megakaryocytes (MKs), and an aberrant cytokine …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by the clonal
expansion of myeloid cells, notably megakaryocytes (MKs), and an aberrant cytokine …

Background Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy.
However, most patients with cancer fail to respond clinically. One potential reason is the …

Background Checkpoint inhibitors targeting PD-1 or PD-L1 are at the forefront of cancer
immunotherapy, however, treating tumors that have primary or acquired resistance to PD …

MATERIALS AND METHODS TGF-β1 is a potent immunosuppressive cytokine produced by
most cells in an inactive, latent form. In its latent form, the mature TGF-β1 dimer is non …

Regulatory T cells (Tregs) are essential to prevent autoimmunity, but excessive Treg function
contributes to cancer progression by inhibiting antitumor immune responses. Tregs exert …

Abstract TGF-β1, β2 and β3 bind a common receptor to exert vastly diverse effects in cancer,
supporting either tumor progression by favoring metastases and inhibiting anti-tumor …

Introduction: Foxp3+ T regulatory cells (Tregs) play critical roles in immune homeostasis
primarily by suppressing many aspects of the immune response. Tregs uniquely express …

GARP is a type I transmembrane protein expressed on regulatory T cells (Tregs) and
platelets. GARP expression has been shown to play an important role in the modulation of …