Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of
vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of …

Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disease of
vasopressin (AVP) neurons. Studies in mouse in vivo models indicate that accumulation of …

The hypothalamic-pituitary system is essential for maintaining life and controlling systemic
homeostasis. However, it can be negatively affected by various diseases, resulting in life …

Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by
variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced …

Recently, various hypothalamic neurons have been successfully engineered from
pluripotent stem cells, including mouse and human embryonic stem cells. Because …

Familial neurohypophyseal diabetes insipidus (FNDI) is a degenerative disorder in which
vasopressin-secreting neurons degenerate over time due to the production of mutant …

The pituitary is a major hormone center that secretes systemic hormones responding to
hypothalamus-derived-releasing hormones. Previously, we reported the independent …

Conclusions• Controlled and scalable differentiation of human pluripotent stem cells
(hPSCs) into pure populations of proopiomelanocortin (POMC) neurons with arcuate …

The hypothalamus orchestrates various essential physiological and behavioral processes
via neuropeptide secretion. The adenohypophysis (anterior pituitary) is a major center for …

Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived
from peripheral blood mononuclear cells of two affected individuals in a family affected by …