After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem
cells (TotiSCs) capable of producing all the differentiated cells in both embryonic and …

Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate
a full organism, including extra-embryonic tissues. A rare population of cells resembling 2 …

Totipotency refers to the ability of a cell to generate all of the cell types of an organism.
Unlike pluripotency, the establishment of totipotency is poorly understood. In mouse …

The female germ line undergoes a unique sequence of differentiation processes that confers
totipotency to the egg,. The reconstitution of these events in vitro using pluripotent stem cells …

The reprogramming of human somatic cells to primed or naive induced pluripotent stem
cells recapitulates the stages of early embryonic development,,,,–. The molecular …

It is challenging to derive totipotent stem cells in vitro that functionally and molecularly
resemble cells from totipotent embryos. Here, we report that a chemical cocktail enables the …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

Despite investigative interest, the artificial derivation of pluripotent stem cells remains
inefficient and incomplete reprogramming hinders its potential as a reliable tool in …

Induced pluripotent stem (iPS) cells can be obtained by the introduction of defined factors
into somatic cells. The combination of Oct4 (also known as Pou5f1), Sox2 and Klf4 (which …