Glutamate excitotoxicity due to its accumulation in the extracellular space is a major factor to
the brain damage that occurs during the early stages of cerebral ischemia 1. GLT-1 is mainly …

Extracellular glutamate contributes to brain damage in ischemia. Under physiological
conditions, glutamate transporters are responsible for regulating its intracellular/extracellular …

Glutamate is the primary excitatory neurotransmitter in the mammalian central nervous
system, which plays an important role in many aspects of normal brain function such as …

Recent evidence suggests that impaired insulin/insulin-like growth factor I (IGF-I) input may
be associated to neurodegeneration. Several major neurodegenerative diseases involve …

During ischemia, the operation of astrocytic/neuronal glutamate transporters is reversed and
glutamate and Na+ are co-transported to the extracellular space. This study aims to …

Although recent results suggest that GluR6 serine phosphorylation plays a prominent role in
brain ischemia/reperfusion-mediated neuronal injury, little is known about the precise …

Glutamate transporters remove glutamate from the extracellular space and maintain it below
neurotoxic levels under normal conditions. However, the dynamics under ischemic …

Maslinic acid (MA), a natural triterpene from Olea europaea L., is a well‐known inhibitor of
glycogen phosphorylase and elicits multiple biological activities. The purpose of this study …

Previous studies have shown that KA receptor subunit GluR6 mediated c-Jun N-terminal
protein kinase (JNK) signaling is involved in global ischemia injury. Our present study …

In this study, we investigated whether the increase of inhibitory γ-amino butyric acid (GABA)
signal suppresses the excitatory glutamate signal induced by cerebral ischemia and the …