Gut-derived systemic inflammation as a driver of depression in chronic liver disease

VT Kronsten, TH Tranah, C Pariante… - Journal of hepatology, 2022 - Elsevier
Depression and chronic liver disease (CLD) are important causes of disability, morbidity and
mortality worldwide and their prevalence continues to rise. The rate of depression in CLD is …

Depression and chronic liver diseases: are there shared underlying mechanisms?

X Huang, X Liu, Y Yu - Frontiers in molecular neuroscience, 2017 - frontiersin.org
The occurrence of depression is higher in patients with chronic liver disease (CLD) than that
in the general population. The mechanism described in previous studies mainly focused on …

Role of peripheral inflammation in hepatic encephalopathy

H Azhari, MG Swain - Journal of clinical and experimental hepatology, 2018 - Elsevier
A growing body of evidence now highlights a key role for systemic inflammation in altering
behavior and mood in patients with liver disease. How inflammation occurring in the …

Depression in patients with cirrhosis (impact on outcome)

N Singh, T Gayowski, MM Wagener… - Digestive diseases and …, 1997 - Springer
The impact of depression (assessed by the BeckDepression Inventory) on quality of life and
outcome wasprospectively assessed in adult patients with cirrhosis. Patients with …

Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut …

M Martin-Subero, G Anderson, B Kanchanatawan… - CNS …, 2016 - cambridge.org
The nature of depression has recently been reconceptualized, being conceived as the
clinical expression of activated immune-inflammatory, oxidative, and nitrosative stress …

Does stress exacerbate liver diseases?

Y Chida, N Sudo, C Kubo - Journal of gastroenterology and …, 2006 - Wiley Online Library
Although anecdotal comments on detrimental effects of psychosocial stress on liver
diseases can be found even in the early literature, only recently has scientific evidence been …

Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

TH Bisgaard, KH Allin, L Keefer… - Nature reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

Depression and anxiety are common among patients with cirrhosis

R Hernaez, JR Kramer, A Khan, J Phillips… - Clinical …, 2022 - Elsevier
Background & Aims Depression and anxiety can have negative effects on patients and are
important to treat. There have been few studies of their prevalence among patients with …

Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?

CD Moulton, P Pavlidis, C Norton… - Clinical & …, 2019 - academic.oup.com
Depressive symptoms are reported by more than 20% of people with inflammatory bowel
disease (IBD), while sleep difficulties and fatigue are even more common. Co-morbid …

Liver-brain inflammation axis

C D'Mello, MG Swain - American Journal of Physiology …, 2011 - journals.physiology.org
It is becoming increasingly evident that peripheral organ-centered inflammatory diseases,
including chronic inflammatory liver diseases, are associated with changes in central neural …