[HTML][HTML] SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway

P Xu, A Luo, C Xiong, H Ren, L Yan, Q Luo - Cancer Cell International, 2022 - Springer
Objectives We aimed to verify the role of signal peptide-CUB-EGF-like domain-containing
protein3 (SCUBE3) in the hepatocellular carcinoma (HCC) progression. Methods The role of …

[HTML][HTML] CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma

J Zhao, R Li, J Li, Z Chen, Z Lin, B Zhang… - Journal of Translational …, 2022 - Springer
Background The tumour microenvironment and cirrhotic liver are excellent sources of cancer-
associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to …

SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer

C Zhao, Q Wang, J Zhang, Y Xu, W Li, M Gu… - Bioscience …, 2013 - jstage.jst.go.jp
Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in
invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in …

[HTML][HTML] Decreased expression of SCUBE2 is associated with progression and prognosis in colorectal cancer

Q Song, C Li, X Feng, A Yu, H Tang… - Oncology …, 2015 - spandidos-publications.com
Signal peptide-CUB-epidermal growth factor-like domain-containing protein 2 (SCUBE2), a
member of the SCUBE protein family, is a secreted and membrane-associated multi-domain …

SCUBE2 inhibits the proliferation, migration and invasion of human non-small cell lung cancer cells through regulation of the sonic hedgehog signaling pathway

B Yang, S Miao, Y Li - Gene, 2018 - Elsevier
Signal peptide-CUB-EGF domain-containing protein 2 (SCUBE2) belongs to a secreted and
membrane-associated multi-domain SCUBE protein family. Recently, it was found to play an …

Activation of tgf-β1 pathway by scube3 regulates twist1 expression and promotes breast cancer progression

X Yang, J Hu, C Shi, J Dai - Cancer Biotherapy & …, 2020 - liebertpub.com
Background: Recently, signal peptide-CUB-EGF-like domain containing protein 3 (SCUBE3)
has been found to be associated with the development of several cancers. However, the …

SCUBE3 exerts a tumor-promoting effect in tongue squamous cell carcinoma by promoting CEBPA binding to the CCL2 promoter

M Zhu, Y Ma, W Wang, M Li, S Chen, F Liu, X Shi… - Molecular Cancer …, 2024 - AACR
Tongue squamous cell carcinoma (TSCC) is the main pathologic subtype of oral cancer, and
the current therapeutic effect is far from satisfactory. The signal peptide-CUB-EGF domain …

SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer

CJ Cheng, YC Lin, MT Tsai, CS Chen, MC Hsieh… - Cancer Research, 2009 - AACR
Signal peptide-CUB-epidermal growth factor–like domain-containing protein 2 (SCUBE2),
originally identified from the endothelium and several nonendothelial primary cell types, was …

[HTML][HTML] SCUBE3 serves as an independent poor prognostic factor in breast cancer

Q Huo, X He, Z Li, F Yang, S He, L Shao, Y Hu… - Cancer Cell …, 2021 - Springer
Background Accumulating evidences indicate that the signal peptide-CUB-EGF-like domain-
containing protein 3 (SCUBE3) plays a key role in the development and progression of …

[HTML][HTML] Overexpression of SCUBE2 inhibits proliferation, migration, and invasion in glioma cells

E Guo, H Liu, X Liu - Oncology Research, 2017 - ncbi.nlm.nih.gov
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the
SCUBE family of proteins, was recently found to play an important role in cancer …