Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼ 21
kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA …

RhoGTPases control cytoskeleton dynamics thereby modulating synaptic plasticity. Because
Alzheimer's disease (AD) is characterized by synaptic dysfunction, we sought to determine …

Introduction 3. Rho GTPase effectors 3.1. Rac/Cdc42/PAK 3.2. Rho/ROCK 3.3. Cdc42/ACK
4. Rho GTPases, neuronal growth cone dynamics, and dendritic spine morphogenesis 5 …

Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …

One of the main research areas in biology from the mid‐1980s through the 1990s was the
elucidation of signaling pathways governing cell responses. These studies brought, among …

The functionality and efficacy of Rho GTPase signaling is pivotal for a plethora of biological
processes. Due to the integral nature of these molecules, the dysregulation of their activities …

Parkinson's disease (PD) is a complex and widespread neurodegenerative disease
characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the …

Background Rho family GTPases are critical regulators of the cytoskeleton and affect cell
migration, cell-cell adhesion, and cell-matrix adhesion. As with all GTPases, their activity is …