Heterogeneous responses and isoform compensation dim the therapeutic window of Hsp90 ATP-binding inhibitors in cancer
X Tang, C Chang, D Mosallaei… - … and Cellular Biology, 2022 - Am Soc Microbiol
The rare capacity for heat shock protein 90 (Hsp90) chaperones to support almost the entire
cellular signaling network was viewed as a potential breakthrough to combat tumor …
cellular signaling network was viewed as a potential breakthrough to combat tumor …
Anticancer inhibitors of Hsp90 function: beyond the usual suspects
The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone responsible for the
stability and function of a wide variety of client proteins that are critical for cell growth and …
stability and function of a wide variety of client proteins that are critical for cell growth and …
Targeting the C-terminus of Hsp90 as a cancer therapy
J McConnell, Y Wang, S McAlpine - Heat Shock Protein Inhibitors: Success …, 2016 - Springer
Classical Hsp90 inhibitors target the N-terminal ATP binding site. While these inhibitors
have had some clinical success, treatment with these molecules leads to a dramatic …
have had some clinical success, treatment with these molecules leads to a dramatic …
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity
The molecular chaperone Hsp90 is an essential and highly abundant central node in the
interactome of eukaryotic cells. Many of its large number of client proteins are relevant to …
interactome of eukaryotic cells. Many of its large number of client proteins are relevant to …
[HTML][HTML] Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors
K Beebe, M Mollapour, B Scroggins, C Prodromou… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Abstract Heat shock protein 90 (Hsp90) is an essential molecular chaperone in eukaryotes
that facilitates the conformational maturation and function of a diverse protein clientele …
that facilitates the conformational maturation and function of a diverse protein clientele …
Hsp90 inhibition: Elimination of shock and stress
AS Duerfeldt, BSJ Blagg - Bioorganic & medicinal chemistry letters, 2010 - Elsevier
The 90kDa heat shock proteins (Hsp90) represent a class of molecular chaperones
responsible for the maturation and stabilization of many oncogenic proteins. Disrupting the …
responsible for the maturation and stabilization of many oncogenic proteins. Disrupting the …
Post-translational modification of heat-shock protein 90: impact on chaperone function
BT Scroggins, L Neckers - Expert opinion on drug discovery, 2007 - Taylor & Francis
Heat-shock protein 90 (Hsp90) is a molecular chaperone required for the stability and
function of many signaling proteins that are often activated, mutated or overexpressed in …
function of many signaling proteins that are often activated, mutated or overexpressed in …
[HTML][HTML] Heat shock protein 90 targeting therapy: state of the art and future perspective
Abstract Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that
plays a role in stabilizing and activating more than 200 client proteins. It is required for the …
plays a role in stabilizing and activating more than 200 client proteins. It is required for the …
Impact of posttranslational modifications on the anticancer activity of Hsp90 inhibitors
MR Woodford, D Dunn, JB Miller, S Jamal… - Advances in cancer …, 2016 - Elsevier
Molecular chaperones are essential for guarding proteins that are indispensable for normal
cellular functions. Heat shock protein 90 (Hsp90) is a vital molecular chaperone in …
cellular functions. Heat shock protein 90 (Hsp90) is a vital molecular chaperone in …
Investigation of the Hsp90 C-terminal binding site, novel inhibitors and isoform-dependent client proteins
LB Peterson - 2012 - kuscholarworks.ku.edu
The heat shock proteins represent an important class of pro-survival proteins that are
intimately involved in cell survival, adaptation to cellular stress, and protein management …
intimately involved in cell survival, adaptation to cellular stress, and protein management …