Globally, the prevalence of chronic pain is high at 10% to 50% of the adult population. 18,
23, 40, 57, 63, 64 Chronic pain not only impairs the quality of life of patients and their …

The opioid epidemic has transformed pain research, not only in the sense of urgency with
which analgesics are being developed, but also in the way in which hypotheses are being …

The American Pain Society estimates that 50 million Americans are partially or totally
disabled by pain. This striking statistic is certain to increase as our population continues to …

Limited options for treating moderate-severe pain led to an overreliance on opioids and the
current opioid epidemic. Addressing the factors contributing to a dearth of effective …

Pain is a major health problem that significantly affects the quality of life of patients. It has a
significant impact on both the sufferers and the broader community, imparting high health …

Management of pain is a fundamental imperative in medicine. Current analgesics suffer from
limitations related to efficacy and adverse events of which abuse potential has assumed an …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Background: Although conventional pain relief therapeutics have centered around μ-opioid
agonists, these drugs are limited by adverse side effects, including respiratory depression …

The “Non-pharmacological treatment of pain” section of the Frontiers in Pain Research was
initiated to reflect the growing appreciation for the role that complementary interventions play …

The worlds of chronic pain and addiction continue to intersect too often in many ways.
Chronic pain significantly impairs and disrupts the quality of life of millions of people …