Lateral habenula and its potential roles in pain and related behaviors

D Dai, W Li, A Chen, XF Gao… - ACS chemical …, 2022 - ACS Publications
The lateral habenula (LHb) is a tiny structure that acts as a hub, relaying signals from the
limbic forebrain structures and basal ganglia to the brainstem modulatory area. Facilitated …

Lateral habenula serves as a potential therapeutic target for neuropathic pain

Y Du, YX Wu, F Guo, FH Qu, TT Hu, B Tan, Y Wang… - Neuroscience …, 2021 - Springer
Neuropathic pain (NeuP) is known as a common and notorious neurological disease,
characterized by spontaneous pain and evoked abnormal pain that includes hypersensitivity …

Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

[HTML][HTML] Lateral habenula in the pathophysiology of depression

Y Yang, H Wang, J Hu, H Hu - Current opinion in neurobiology, 2018 - Elsevier
Depression is a devastating disorder with a combination of diverse symptoms such as low
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …

[HTML][HTML] Dysregulation of the lateral habenula in major depressive disorder

CA Browne, R Hammack, I Lucki - Frontiers in synaptic neuroscience, 2018 - frontiersin.org
Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …

[HTML][HTML] Synaptic and cellular profile of neurons in the lateral habenula

FJ Meye, S Lecca, K Valentinova… - Frontiers in human …, 2013 - frontiersin.org
The lateral habenula (LHb) is emerging as a crucial structure capable of conveying
rewarding and aversive information. Recent evidence indicates that a rapid increase in the …

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

S Lecca, FJ Meye, M Mameli - European Journal of …, 2014 - Wiley Online Library
The lateral habenula (LH b) is an epithalamic region with a crucial role in the regulation of
midbrain monoaminergic systems. Over the past few years a renewed interest in the LH b …

Unmasking the mysteries of the habenula in pain and analgesia

L Shelton, L Becerra, D Borsook - Progress in neurobiology, 2012 - Elsevier
The habenula is a small bilateral structure in the posterior–medial aspect of the dorsal
thalamus that has been implicated in a remarkably wide range of behaviors including …

[HTML][HTML] The role of the habenula in drug addiction

KM Velasquez, DL Molfese, R Salas - Frontiers in human …, 2014 - frontiersin.org
Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …