The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …

MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma
(HNSCC). Unexpectedly, MAPK pathway aberrations are associated with remarkably long …

Head and neck squamous cell carcinomas (HNSCC) represent a multifactorial disease of
poor prognosis. They have lagged behind other cancers in terms of personalized therapy …

Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common
cancer worldwide, with high mortality and a lack of targeted therapies. To identify and …

Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous
cell carcinoma (HNSCC) treatment, but< 20% of patients achieve durable responses …

Abstract 234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from
homogeneously treated patients with locally advanced head and neck squamous cell …

Two studies published in this issue of Cancer Discovery describe the emerging mutational
landscape of head and neck squamous cell carcinomas (HNSCC) and their genomic and …

The treatment of head and neck squamous cell carcinoma (HNSCC) is set to undergo rapid
changes, as novel treatment targets informed by genomic profiling and novel molecularly …

Head and neck squamous cell carcinoma (HNSCC) encompasses a diverse group of
malignancies originating in the oral cavity, oropharynx, larynx and hypopharynx. Although …

Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …