Physiologically Inspired Mucin Coated Escherichia coli Nissle 1917 Enhances Biotherapy by Regulating the Pathological Microenvironment to Improve Intestinal …
X Yang, J Yang, Z Ye, G Zhang, W Nie, H Cheng… - ACS …, 2022 - ACS Publications
The delivery of probiotics to the microbiota is a promising method to prevent and treat
diseases. However, oral probiotics will suffer from gastrointestinal insults, especially the …
diseases. However, oral probiotics will suffer from gastrointestinal insults, especially the …
Biomaterials coating for on-demand bacteria delivery: Selective release, adhesion, and detachment
Bacteria-based therapy has shown great promise in treating various diseases by regulating
intestinal flora balance in pre-clinical and clinical studies. However, weak resistance against …
intestinal flora balance in pre-clinical and clinical studies. However, weak resistance against …
An oral “Super probiotics” with versatile self-assembly adventitia for enhanced intestinal colonization by autonomous regulating the pathological microenvironment
J Yang, G Zhang, X Yang, M Peng, S Ge, S Tan… - Chemical Engineering …, 2022 - Elsevier
Transplanting beneficial bacteria to gut microbiome can positively modulate microbiome
composition and is a promising strategy to prevent and treat diseases. However, oral …
composition and is a promising strategy to prevent and treat diseases. However, oral …
[HTML][HTML] Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery
J Zhou, M Li, Q Chen, X Li, L Chen, Z Dong… - Nature …, 2022 - nature.com
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …
Modified prebiotic-based “shield” armed probiotics with enhanced resistance of gastrointestinal stresses and prolonged intestinal retention for synergistic alleviation of …
Oral administration of probiotics is a promising method to alleviate inflammatory bowel
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …
Gastrointestinal Microenvironment Responsive Nanoencapsulation of Probiotics and Drugs for Synergistic Therapy of Intestinal Diseases
P Peng, T Feng, X Yang, C Nie, L Yu, R Ding, Q Zhou… - ACS …, 2023 - ACS Publications
The gut microbiota are prominent in preserving intestinal environmental homeostasis and
managing human health, and their dysbiosis has been directly related to many kinds of …
managing human health, and their dysbiosis has been directly related to many kinds of …
Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
Bionic regulators break the ecological niche of pathogenic bacteria for modulating dysregulated microbiome in colitis
J Yang, G Zhang, M Peng, S Tan, S Ge… - Advanced …, 2022 - Wiley Online Library
Therapeutic approaches that reprogram the gut microbiome are promising strategies to
alleviate and cure inflammatory bowel disease (IBD). However, abnormal expansion of …
alleviate and cure inflammatory bowel disease (IBD). However, abnormal expansion of …
Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis
J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …
efficacy and underlying safety problems have limited their clinical application. Herein …
Prodrug integrated envelope on probiotics to enhance target therapy for ulcerative colitis
K Zhang, L Zhu, Y Zhong, L Xu, C Lang… - Advanced …, 2023 - Wiley Online Library
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …