Introduction The global health burden of stroke is significant and few therapeutic treatment
options currently exist for patients. Pre-clinical research relies heavily on rodent stroke …

Stroke is one of the world's leading causes of death and disability, posing enormous burden
to the society. However, the pathogenesis and mechanisms that underlie brain injury and …

Translation from basic science bench research in ischemic stroke to bedside treatment of
patients suffering ischemic stroke remains a difficult challenge. Despite literally hundreds of …

Stroke is a leading cause of death and disability worldwide. Effective intervention for acute
stroke remains to be a significant unmet medical need. In the past several decades, a large …

Neurological diseases, including neurodegenerative and neurodevelopmental disorders,
affect nearly one in six of the world's population. The burden of the resulting deaths and …

Introduction: Representing the leading cause of long-term disability, ischemic stroke urgently
needs further research and drug development. This review summarizes current animal …

Stroke is one of the major healthcare challenges prevailing across the globe due to its
significant rate of mortality and morbidity. Stroke is multifactorial in nature and involves …

We previously generated an ischemic stroke in a zebrafish model using N 2 gas perfusion;
however, this model was an unsuitable drug screening system due to low throughput. In this …

Zebrafish have recently acquired the attention of the research community as a model to
study neurological pathologies and behavioural anomalies. The small size and high …

Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the
hallmarks of cerebrovascular disease. While there are many genetic and environmental …