Background Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM)
contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile …

Excessive airway obstruction is the cause of symptoms and abnormal lung function in
asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is …

The cause-and-effect relationship between airway smooth muscle (ASM) remodeling and
airway hyperresponsiveness (AHR) following allergen challenge is not well established …

Objective: To determine a change in airway smooth muscle contractility in a murine model of
allergic asthma, the responsiveness of airway smooth muscles isolated from ovalbumin (OA) …

Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling
evidence now suggests that the key features of asthma in part are due to intrinsic differences …

BACKGROUND: Airway remodeling in asthma comprises a range of structural changes.
Several studies have suggested an association between these changes and disease …

It has long been known that airway smooth muscle (ASM) contraction contributes
significantly to the reversible airflow obstruction that defines asthma. It has also been …

Airway smooth muscle (ASM) was first described in 1804 by Franz Daniel Reisseisen (as
related by Otis (1983))[1], and the “irritability” of ASM and its potential contribution to asthma …

Asthma is a disease characterized, in part, by airway hyperresponsiveness and
inflammation. Although asthma typically induces reversible airway obstruction, in some …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …