Human neural stem cell secretome inhibits lipopolysaccharide-induced neuroinflammation through modulating microglia polarization by activating peroxisome …

J Zhou, W Ni, Y Ling, X Lv, D Niu, Y Zeng… - Stem Cells and …, 2022 - liebertpub.com
Neuroinflammation is one of the typical events in multiple neurodegenerative diseases,
whereas microglia are the critical participants in the pathogenesis of neuroinflammation …

Immunomodulatory and anti-inflammatory effect of neural stem/progenitor cells in the central nervous system

W Ni, M Ramalingam, Y Li, JH Park… - Stem Cell Reviews and …, 2023 - Springer
Neuroinflammation is a critical event that responds to disturbed homeostasis and governs
various neurological diseases in the central nervous system (CNS). The excessive …

[HTML][HTML] A new strategy for the regulation of neuroinflammation: exosomes derived from mesenchymal stem cells

Y Ge, J Wu, L Zhang, N Huang, Y Luo - Cellular and Molecular …, 2024 - Springer
Neuroinflammation is an important pathogenesis of neurological diseases and causes a
series of physiopathological changes, such as abnormal activation of glial cells, neuronal …

Mesenchymal stem cells enhance microglia M2 polarization and attenuate neuroinflammation through TSG-6

Y Liu, R Zeng, Y Wang, W Huang, B Hu, G Zhu… - Brain Research, 2019 - Elsevier
Microglia are the primary cells that exert immune function in the central nervous system
(CNS), and they play an important role in the pathogenesis and progression of …

[HTML][HTML] Proficiency of extracellular vesicles from hiPSC-derived neural stem cells in modulating proinflammatory human microglia: role of pentraxin-3 and miRNA-21 …

R Upadhya, LN Madhu, S Rao… - Frontiers in Molecular …, 2022 - frontiersin.org
Extracellular vesicles (EVs) shed by human-induced pluripotent stem cell (hiPSC)-derived
neural stem cells (hNSC-EVs) have shown potent antiinflammatory properties in a mouse …

Interleukin-1β-treated mesenchymal stem cells inhibit inflammation in hippocampal astrocytes through exosome-activated Nrf-2 signaling

K Liu, GL Cai, Z Zhuang, SY Pei, SN Xu… - International Journal …, 2021 - Taylor & Francis
Background Interleukin-1β (IL-1)-treated mesenchymal stem cells (MSCs) and IL-1-MSCs-
conditioned medium (CM) exert anti-inflammatory roles. Astrocytes are essential for the …

MSC-Derived Extracellular Vesicles Alleviate NLRP3/GSDMD-Mediated Neuroinflammation in Mouse Model of Sporadic Alzheimer's Disease

L Lin, L Huang, S Huang, W Chen, H Huang… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease, with sporadic
form being the predominant type. Neuroinflammation plays a critical role in accelerating …

The secretome of microglia regulate neural stem cell function

AM Osman, J Rodhe, X Shen, CA Dominguez… - Neuroscience, 2019 - Elsevier
Brain injury is associated with neuroinflammation, and microglia are key players in this
process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how …

[HTML][HTML] Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6

Y Liu, R Zhang, K Yan, F Chen, W Huang, B Lv… - Journal of …, 2014 - Springer
Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated
inflammation is associated with the pathogenesis of various neuronal disorders. Recently …

[HTML][HTML] Bone marrow mesenchymal stem cells-secreted exosomal H19 modulates lipopolysaccharides-stimulated microglial M1/M2 polarization and alleviates …

L Zong, P Huang, Q Song, Y Kang - American Journal of …, 2021 - ncbi.nlm.nih.gov
Neuroinflammation is the most common cause of neurological diseases. Exosomes derived
from mesenchymal stem cells (MSCs-exos) have been reported to reduce inflammation and …