Specificity protein (Sp) is a famous family of transcription factors including Sp1, Sp2 and
Sp3. Sp1 is the first one of Sp family proteins to be characterized and cloned in mammalian …

Sp1 is a transcription factor regulating many genes through its DNA binding domain,
containing three zinc fingers. We were interested in identifying target genes regulated by …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

The transcription factor Sp1 regulates expression of numerous genes involved in many
cellular processes. Different post-transcriptional modifications can influence the …

Abstract Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the
expression of numerous genes involved in cell proliferation, apoptosis, and differentiation …

Atherosclerosis and restenosis are common vascular disorders that involve excess
proliferation of smooth muscle cells (SMCs) in the artery wall. In this study we demonstrate …

Sp1, the first identified and cloned transcription factor, regulates gene expression via
multiple mechanisms including direct protein–DNA interactions, protein–protein interactions …

The role of specificity protein 1 (Sp1) in controlling gene expression in lung tumor
development and metastasis is not well understood. In this study, we showed that the Sp1 …

Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1
and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They …

Background Sp1, an important transcription factor, is involved in the progression of various
cancers. Our previous studies have indicated that Sp1 levels are increased in the early …