From Cold to Killer: How SARS-CoV-2 Evolved without Hemagglutinin Esterase to Agglutinate and Then Clot Blood Cells

D Scheim - 2022 - osf.io
The role of vascular occlusion in the morbidities, pulmonary and systemic, of COVID-19 has
received increasing focus. Histological studies of lung tissue from COVID-19 patients have …

Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses

DE Scheim, PI Parry, DJ Rabbolini, C Aldous… - Viruses, 2024 - mdpi.com
Consistent with the biochemistry of coronaviruses as well established over decades, SARS-
CoV-2 makes its initial attachment to host cells through the binding of its spike protein (SP) …

Endothelial dysfunction and COVID‑19

J Daher - Biomedical Reports, 2021 - spandidos-publications.com
It is hypothesized that several comorbidities increase the severity of COVID‑19 symptoms.
Cardiovascular disease including hypertension was shown to play a critical role in the …

Vascular underpinning of COVID-19

V Wazny, A Siau, KX Wu, C Cheung - Open Biology, 2020 - royalsocietypublishing.org
COVID-19 management guidelines have largely attributed critically ill patients who develop
acute respiratory distress syndrome, to a systemic overproduction of pro-inflammatory …

COVID-19 sepsis and microcirculation dysfunction

A Colantuoni, R Martini, P Caprari, M Ballestri… - Frontiers in …, 2020 - frontiersin.org
The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a
great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more …

Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection

H Okada, S Yoshida, A Hara, S Ogura… - …, 2021 - Wiley Online Library
The potential for a rapid increase in severity is among the most frightening aspects of severe
acute respiratory syndrome coronavirus 2 infection. Evidence increasingly suggests that the …

Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement

KR Stenmark, MG Frid… - Pulmonary …, 2021 - journals.sagepub.com
The outbreak of COVID-19 disease, caused by SARS-CoV-2 beta-coronovirus, urges a
focused search for the underlying mechanisms and treatment options. The lung is the major …

Immunoinflammatory, thrombohaemostatic, and cardiovascular mechanisms in COVID-19

S Gencer, M Lacy, D Atzler… - Thrombosis and …, 2020 - thieme-connect.com
The global coronavirus disease 2019 (COVID-19) pandemic has deranged the recent
history of humankind, afflicting more than 27 million individuals to date. While the majority of …

[HTML][HTML] Editorial commentary: vascular injury in acute infections and COVID-19: everything old is new again

JH Levy, T Iba, JM Connors - Trends in Cardiovascular Medicine, 2021 - ncbi.nlm.nih.gov
In the current edition of the journal, Siddiqi and colleagues discuss the role of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated endothelial injury, and discuss …

Clotting and SARS-CoV-2 entry

U Hofer - Nature Reviews Microbiology, 2022 - nature.com
The cost of resistance Page 1 in brief 0123456789();: nature reviews | Microbiology
MICROBIOME Mobilizing resistance genes in the human gut Antibiotic resistance genes (ARGs) …