Potential predictive and therapeutic applications of small extracellular vesicles-derived circPARD3B in osteoarthritis

Z Lin, Y Ma, X Zhu, S Dai, W Sun, W Li, S Niu… - Frontiers in …, 2022 - frontiersin.org
Background: Heterogeneous phenotypes that display distinct common characteristics of
osteoarthritis (OA) are not well defined and will be helpful in identifying more customized …

Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis

Z Guo, H Wang, F Zhao, M Liu, F Wang, M Kang… - Arthritis research & …, 2021 - Springer
Abstract Background Circular RNAs (circRNAs) can act as vital players in osteoarthritis (OA).
However, the roles of circRNAs in OA remain obscure. Herein, we explored the roles of …

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene

S Shen, Y Wu, J Chen, Z Xie, K Huang… - Annals of the …, 2019 - ard.bmj.com
Objectives Circular RNAs (circRNA) expression aberration has been identified in various
human diseases. In this study, we investigated whether circRNAs could act as competing …

Biological roles and therapeutic potential of circular RNAs in osteoarthritis

X Mao, Y Cao, Z Guo, L Wang, C Xiang - Molecular Therapy-Nucleic Acids, 2021 - cell.com
Osteoarthritis (OA) is a common and disabling joint disorder that is mainly characterized by
cartilage degeneration and narrow joint spaces. The regulatory functions of non-coding …

circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

S Shen, Y Yang, P Shen, J Ma, B Fang… - Annals of the …, 2021 - ard.bmj.com
Objectives Circular RNAs (circRNAs) have emerged as significant biological regulators.
Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is …

Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

W Zhang, L Qi, R Chen, J He, Z Liu, W Wang… - Arthritis Research & …, 2021 - Springer
Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked
intensive interest. Initially considered as the transcriptional noises, further studies have …

[HTML][HTML] CircRNAs in osteoarthritis: research status and prospect

Z Li, J Lu - Frontiers in Genetics, 2023 - frontiersin.org
Osteoarthritis (OA) is the most common joint disease globally, and its progression is
irreversible. The mechanism of osteoarthritis is not fully understood. Research on the …

Therapeutic potential of exosomal circRNA derived from synovial mesenchymal cells via targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF functional module in …

J Zhang, Y Zhang, Y Ma, L Luo, M Chu… - International Journal of …, 2021 - Taylor & Francis
Background Synovial inflammation and its associated activation of angiogenesis play critical
roles in rheumatoid arthritis (RA). Exosomes, as carriers of genetic information including …

Circ_0110251 overexpression alleviates IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in …

Y Zhang, H Zheng, B Li - Autoimmunity, 2022 - Taylor & Francis
Background Mounting evidence indicates that circular RNAs (circRNAs) are involved in the
progression of human diseases, including osteoarthritis (OA). In this study, we focussed on …

Silencing of circ-PRKCH protects against lipopolysaccharide (LPS)-evoked chondrocyte damage and extracellular matrix loss by the miR-140-3p/ADAM10 axis.

J Zhao, T Li, W Luo - General Physiology & Biophysics, 2021 - search.ebscohost.com
Circular RNAs (circRNAs) have been implicated in the pathology of osteoarthritis (OA).
Nevertheless, the precise actions of circRNA protein kinase C eta (circ-PRKCH …