Exploration of the Components and Pharmacological Mechanisms of Keyin Pill‐Induced Liver Injury Based on Network Pharmacology

B Xing, Y Cui, Y Chen, L Lai, M Zhang… - Evidence‐Based …, 2022 - Wiley Online Library
Background. Keyin pill (KP), a patented medicine in China, is used to treat psoriasis.
However, KP has been reported to have liver toxicity, but its toxic substance basis and …

Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury

LUO Yun-Xia, W Xin-Yue, YJ Huang… - Chinese journal of …, 2018 - Elsevier
Liver injury remains a significant global health problem and has a variety of causes,
including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently …

Systematic elucidation of the potential mechanism of Erzhi pill against drug‐induced liver injury via network pharmacology approach

S Huang, F Mu, F Li, W Wang, W Zhang… - Evidence‐Based …, 2020 - Wiley Online Library
Objective. The purpose of this work was to investigate the bioactive compounds, core genes,
and pharmacological mechanisms and to provide a further research orientation of Erzhi pill …

Network pharmacology and in vivo studies reveal the pharmacological effects and molecular mechanisms of Celastrol against acute hepatic injury induced by LPS

T Yang, S Zhao, N Sun, Y Zhao, H Wang… - International …, 2023 - Elsevier
Sepsis is currently the main factor of death in the ICU, and the liver, as an important organ of
immunity and stable metabolism, can be acutely damaged during sepsis, and the mortality …

Study on the effect of active components of Schisandra chinensis on liver injury and its mechanisms in mice based on network pharmacology

G Xu, X Lv, Y Feng, H Li, C Chen, H Lin, H Li… - European Journal of …, 2021 - Elsevier
The aim of this study was to analyze the active components of Schisandra chinensis on liver
injury and its mechanism in mice by network pharmacology. The active components of S …

Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of …

Y Jiang, M Zhong, H Zhan, X Tao, Y Zhang… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Penthorum chinense Pursh (PCP, Saxifragaceae)
is an edible plant and frequently-used Chinese herbal medicine, and is commonly used as …

Mechanism of Sini Powder on protecting liver based on network pharmacology

HL FENG - Chinese Traditional and Herbal Drugs, 2020 - pesquisa.bvsalud.org
Objective: To explore the material basis and hepatoprotective mechanism of Sini Powder in
the treatment of chronic hepatitis, fatty liver and liver cancer based on network …

[HTML][HTML] Exploring the potential mechanisms of Shiwei Hezi pill against nephritis based on the method of network pharmacology

L Wei - Frontiers in Pharmacology, 2023 - frontiersin.org
Objective: We aimed to reveal the potential active ingredients, targets and pathways of
Shiwei Hezi pill (SHP) in the treatment of nephritis based on systematic network …

[PDF][PDF] A network pharmacology approach to investigate the mechanisms of Huangqin decoction in the treatment of irinotecan-induced gastrointestinal toxicity

Y Wang, Q Xu, ZQ Feng - Asian Toxicology Research, 2020 - tmrjournals.cn
Objective: To find out the potential mechanisms of Huangqin decoction in the treatment of
irinotecan-induced gastrointestinal toxicity. Methods: A network pharmacology approach …

Naringenin inhibits APAP-induced acute liver injury through activating PPARA-dependent signaling pathway

J Xu, J Chen, J Deng, X Chen, R Du, Z Yu… - Experimental Cell …, 2024 - Elsevier
Acute liver injury (ALI) refers to the damage to the liver cells of patients due to drugs, food,
and diseases. In this work, we used a network pharmacology approach to analyze the …