Oxidative stress, resulting from an imbalance between the formation of damaging free
radicals and availability of protective antioxidants, can contribute to peripheral neuropathic …

Chronic pain remains an enormous health problem affecting approximatively 30% of the
world's population. Opioids as the first line analgesics often leads to undesirable side effects …

Background. Neuropathic pain is a debilitating disease with few effective treatments.
Emerging evidence indicates the involvement of mitochondrial dysfunction and oxidative …

Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …

The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) exerts potent antioxidative
and anti-inflammatory effects; however, its participation in the modulation of chronic …

Different aspects involved in pathophysiology of diabetic neuropathy are related to
inflammatory and apoptotic pathways. This article summarizes evidence that Nrf2 acts as a …

Reduction in Nrf2-mediated antioxidant response in the central nervous system plays an
important role in the development and maintenance of neuropathic pain (NP). However, the …

Abstract Nuclear factor (erythroid derived)-2 like 2 (NFE2L2), also known as nuclear factor
erythroid 2 (NF-E2)-related factor 2 (Nrf2), is a ubiquitous transcription factor essential for …

Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a
central role in cellular defense against oxidative and electrophilic insults by timely induction …

Chronic neuropathic pain is associated with anxiety-and depressive-like disorders. Its
treatment remains a serious clinical problem due to the lack of efficacy of the available …