The toxin and antitoxin modules in bacteria consist of a toxin molecule that has activity to
inhibit various cellular processes and its cognate antitoxin that neutralizes the toxin. This …

Bacterial persistence is characterized by the ability of a subpopulation within bacterial
cultures to survive exposure to antibiotics and other lethal treatments. The surviving …

Non-typhoidal Salmonella strains are responsible for invasive infections associated with
high mortality and recurrence in sub-Saharan Africa, and there is strong evidence for clonal …

Bacterial persister cells are considered a basis for chronic infections and relapse caused by
bacterial pathogens. Persisters are phenotypic variants characterized by low metabolic …

Persisters are multidrug-tolerant bacteria that could account for the relapse of infections. For
a long time, persisters have been assumed to be nonreplicating dormant bacteria, but the …

It is a given that new antibiotics are needed to combat drug-resistant pathogens. However,
this is only a part of the need—we actually never had antibiotics capable of eradicating an …

Objective Persister cells are a specific subset of bacteria capable of surviving exposure to
lethal doses of antibiotics, leading to antibiotic therapy failures and infection relapses. This …

Bacteria can withstand killing by bactericidal antibiotics through phenotypic changes
mediated by their preexisting genetic repertoire. These changes can be exhibited transiently …

Bacterial persisters survive antibiotic treatment and can cause chronic infections. In this
issue of Science Signaling, Pontes and Groisman suggest that there is no specific molecular …

Antibiotics are powerful therapeutics but are not equally effective against all cells in bacterial
populations. Bacteria that express an antibiotic-tolerant phenotype (" persisters") can evade …