The RNA-binding protein ProQ promotes antibiotic persistence in Salmonella

A Rizvanovic, C Michaux, M Panza, Z Iloglu, S Helaine… - MBio, 2022 - Am Soc Microbiol
Bacterial populations can survive exposure to antibiotics through transient phenotypic and
gene expression changes. These changes can be attributed to a small subpopulation of …

Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain

A Rizvanovic, J Kjellin, F Söderbom… - Nucleic acids …, 2021 - academic.oup.com
The global RNA-binding protein ProQ has emerged as a central player in post-
transcriptional regulatory networks in bacteria. While the N-terminal domain (NTD) of ProQ …

The major RNA-binding protein ProQ impacts virulence gene expression in Salmonella enterica serovar Typhimurium

AJ Westermann, E Venturini, ME Sellin, KU Förstner… - MBio, 2019 - Am Soc Microbiol
FinO domain proteins such as ProQ of the model pathogen Salmonella enterica have
emerged as a new class of major RNA-binding proteins in bacteria. ProQ has been shown to …

ProQ-dependent activation of Salmonella virulence genes mediated by post-transcriptional control of PhoP synthesis

S Bergman, L Andresen, J Kjellin, Y Martinez Burgo… - Msphere, 2024 - Am Soc Microbiol
Gastrointestinal disease caused by Salmonella enterica is associated with the pathogen's
ability to replicate within epithelial cells and macrophages. Upon host cell entry, the bacteria …

[HTML][HTML] Global maps of ProQ binding in vivo reveal target recognition via RNA structure and stability control at mRNA 3′ ends

E Holmqvist, L Li, T Bischler, L Barquist, J Vogel - Molecular cell, 2018 - cell.com
The conserved RNA-binding protein ProQ has emerged as the centerpiece of a previously
unknown third large network of post-transcriptional control in enterobacteria. Here, we have …

Grad-seq guides the discovery of ProQ as a major small RNA-binding protein

A Smirnov, KU Förstner, E Holmqvist… - Proceedings of the …, 2016 - National Acad Sciences
The functional annotation of transcriptomes and identification of noncoding RNA (ncRNA)
classes has been greatly facilitated by the advent of next-generation RNA sequencing …

Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ

S Pandey, CM Gravel, OM Stockert… - Nucleic acids …, 2020 - academic.oup.com
Abstract The FinO-domain-protein ProQ is an RNA-binding protein that has been known to
play a role in osmoregulation in proteobacteria. Recently, ProQ has been shown to act as a …

RNA chaperones step out of Hfq's shadow

L Attaiech, JNM Glover, X Charpentier - Trends in microbiology, 2017 - cell.com
The stability and function of regulatory small RNAs (sRNAs) often require a specialized RNA-
binding protein called an RNA chaperone. Recent findings show that proteins containing a …

The FinO/ProQ-like protein PA2582 impacts antimicrobial resistance in Pseudomonas aeruginosa

A Cianciulli Sesso, A Resch, I Moll, U Bläsi… - Frontiers in …, 2024 - frontiersin.org
Bacteria employ small regulatory RNAs (sRNA) and/or RNA binding proteins (RBPs) to
respond to environmental cues. In Enterobacteriaceae, the FinO-domain containing RBP …

Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease

Y El Mouali, F Ponath, V Scharrer, N Wenner… - Rna, 2021 - rnajournal.cshlp.org
The FinO-domain protein ProQ belongs to a widespread family of RNA-binding proteins
(RBPs) involved in gene regulation in bacterial chromosomes and mobile elements. While …