The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and
spatiotemporal changes of the microenvironment in the pathological process provide vital …

Transplantation with mesenchymal stem cells (MSCs) has been reported to promote
functional recovery in animal models of ischemic stroke. However, the molecular …

An emerging paradigm in the treatment of stroke in patients with fixed neurologic deficits is
stem cell therapy. Mesenchymal stem cells (MSCs) are attractive candidate cells for …

Ischemic stroke is a leading cause of death worldwide; currently available treatment
approaches for ischemic stroke are to restore blood flow, which reduce disability but are time …

There is currently no treatment for restoring lost neurological function after stroke. A growing
number of studies have highlighted the potential of stem cells. However, the mechanisms …

Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However,
despite many years of preclinical research, the application of stem cells is still limited to the …

Human adipose-derived mesenchymal stem cells (hAMSCs) are capable of
immunomodulation and regeneration after neural injury. For these reasons, hAMSCs have …

Ischemic stroke is typified by hypoxia and a cascade of pathophysiological events, including
metabolic dysfunction, ionic dysregulation, excitotoxicity, inflammatory infiltration, and …

As the greatest medical and socioeconomic problem in developing countries, stroke is the
second or third leading cause of death in China and worldwide. In adult organisms suffering …

Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) hold great promise
as a cell source for transplantation into injured tissues to alleviate inflammation. However …