Central nervous system tumors related to gliomas are of neuroectodermal origin and cover
about 30% of all primary brain tumors. Glioma is not susceptible to any therapy and surgical …

Glioblastoma (GBM) is the most frequent and aggressive primary adult brain tumor with poor
prognosis. Epidermal growth factor receptor variant III (EGFRvIII) is the most common and …

Glioblastoma multiforme (GBM) is the most prevalent and lethal malignant intracranial tumor
in the brain, with very poor prognosis and survival. The epidermal growth factor receptor …

Epidermal growth factor receptor variant III (EGFRvIII) is the most prevalent EGFR mutant
found in glioblastoma (GBM). Due to a truncation of large portion of the extracellular region …

EGFRvIII is expressed only in tumor cells and strongly in glioblastoma and is considered a
promising target in cancer diagnosis and therapy. Aptamers are synthetic single-stranded …

Nucleic-acid aptamers are of strong interest for diagnosis and therapy. Compared with
antibodies, they are smaller, stable upon variations in temperature, easy to modify, and have …

Malignant glioma is the most prevalent and lethal primary brain tumor. Due to molecular
heterogeneity and organ-specific clinical manifestations, it is essential to improve glioma …

Aim: Aptamers are oligonucleic acid or peptide molecules that bind to a specific target
molecule in cells, thus may act as effective vehicles for drug or siRNA delivery. In this study …

Background Glioblastoma is the most common and most lethal form of brain tumor in human.
Unfortunately, there is still no effective therapy to this fatal disease and the median survival …

Glioblastoma (GBM) is the most lethal primary brain tumor of the central nervous system in
adults. Despite advances in surgical and medical neuro-oncology, the median survival is …