[HTML][HTML] Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

[HTML][HTML] Immunobiology of atherosclerosis: a complex net of interactions

B Herrero-Fernandez, R Gomez-Bris… - International Journal of …, 2019 - mdpi.com
Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

How the immune system shapes atherosclerosis: roles of innate and adaptive immunity

P Roy, M Orecchioni, K Ley - Nature Reviews Immunology, 2022 - nature.com
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …

[HTML][HTML] Immunity, atherosclerosis and cardiovascular disease

J Frostegård - BMC medicine, 2013 - Springer
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

The interplay of lipids, lipoproteins, and immunity in atherosclerosis

A Pirillo, F Bonacina, GD Norata… - Current atherosclerosis …, 2018 - Springer
Abstract Purpose of Review Atherosclerosis is an inflammatory disorder of the arterial wall,
in which several players contribute to the onset and progression of the disease. Besides the …

[HTML][HTML] The why and how of adaptive immune responses in ischemic cardiovascular disease

Z Mallat, CJ Binder - Nature cardiovascular research, 2022 - nature.com
Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

[HTML][HTML] Immune effector mechanisms implicated in atherosclerosis: from mice to humans

P Libby, AH Lichtman, GK Hansson - Immunity, 2013 - cell.com
According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

The immune response in atherosclerosis: a double-edged sword

GK Hansson, P Libby - Nature reviews immunology, 2006 - nature.com
Immune responses participate in every phase of atherosclerosis. There is increasing
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …

Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review

TX Zhao, Z Mallat - Journal of the American College of Cardiology, 2019 - jacc.org
Atherosclerosis has long been known as an inflammatory disease. However, whether
targeting inflammation improves outcomes was unproven until the recent results of CANTOS …

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

P Welsh, G Grassia, S Botha, N Sattar… - British journal of …, 2017 - Wiley Online Library
Data from basic science experiments is overwhelmingly supportive of the causal role of
immune‐inflammatory response (s) at the core of atherosclerosis, and therefore, the …