Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank
Background Genetic and lifestyle factors have considerable effects on obesity and related
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …
diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank …
Dissecting the clinical relevance of polygenic risk score for obesity—a cross-sectional, longitudinal analysis
EK Choe, M Shivakumar, SM Lee, A Verma… - International Journal of …, 2022 - nature.com
Background Obesity is a global pandemic disease whose prevalence is increasing
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
worldwide. The clinical relevance of a polygenic risk score (PRS) for obesity has not been …
Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits: the GLACIER Study
Background: Recent cross-sectional genome-wide scans have reported associations of 97
independent loci with body mass index (BMI). In 3541 middle-aged adult participants from …
independent loci with body mass index (BMI). In 3541 middle-aged adult participants from …
Association of a genetic risk score with body mass index across different birth cohorts
Importance Many genetic variants are associated with body mass index (BMI). Associations
may have changed with the 20th century obesity epidemic and may differ for black vs white …
may have changed with the 20th century obesity epidemic and may differ for black vs white …
Associations of genetic risk score with obesity and related traits and the modifying effect of physical activity in a Chinese Han population
Background/Objectives Recent large-scale genome-wide association studies have identified
multiple loci robustly associated with BMI, predominantly in European ancestry (EA) …
multiple loci robustly associated with BMI, predominantly in European ancestry (EA) …
The effect of GWAS identified BMI loci on changes in body weight among middle‐aged Danes during a five‐year period
CH Sandholt, KH Allin, U Toft, A Borglykke… - …, 2014 - Wiley Online Library
Objective Genome‐wide association studies have identified genetic variants associating
with BMI, however, it is un‐clarified whether the same variants also influence body weight …
with BMI, however, it is un‐clarified whether the same variants also influence body weight …
[HTML][HTML] Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
S Li, JH Zhao, RN Luben, SA Rodwell, KT Khaw… - The American journal of …, 2010 - Elsevier
Background: Large-scale genome-wide association studies have identified 12 genetic loci
that are robustly associated with body mass index (BMI). Objectives: We examined …
that are robustly associated with body mass index (BMI). Objectives: We examined …
Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status
M Rask-Andersen, T Karlsson, WE Ek… - PLoS genetics, 2017 - journals.plos.org
Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci
to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ …
to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ …
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
Objective: Several genome–wide association studies (GWAS) have demonstrated that
common genetic variants contribute to obesity. However, studies of this complex trait have …
common genetic variants contribute to obesity. However, studies of this complex trait have …
Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK …
Objective To investigate whether the association between a genetic profile risk score for
obesity (GPRS-obesity)(based on 93 SNPs) and body mass index (BMI) was modified by …
obesity (GPRS-obesity)(based on 93 SNPs) and body mass index (BMI) was modified by …