Increased Nogo-B receptor (NGBR) expression in the liver improves insulin sensitivity by
reducing endoplasmic reticulum stress (ER stress) and activating the AMPK pathway …

Liver fibrosis is an important pathologic process in response to chronic or repetitive liver
injury. It can advance to liver cirrhosis. Both peroxisome proliferator-activated receptor …

Recent evidence suggests that troxerutin, a trihydroxyethylated derivative of natural
bioflavonoid rutin, exhibits beneficial effects on diabetes-related symptoms. Here we …

The reduction of insulin resistance or improvement of insulin sensitivity is the most effective
treatment for type 2 diabetes (T2D). We previously reported that Nogo-B receptor (NGBR) …

Members of the nuclear receptor superfamily have vital roles in regulating immunity and
inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to …

Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …

Obesity is a risk factor for insulin resistance, type 2 diabetes, and cardiovascular diseases.
Reticulon-4 (Nogo) is an endoplasmic reticulum–resident protein with unclear functions in …

Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …

Nogo‐B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER
structure and function. Because ER stress is known to induce M2 macrophage polarization …

Aim To evaluate plasma N ogo‐B levels in liver cirrhotic patients and declare a novel
molecular basis by which N ogo‐B modulates hepatic stellate cell (HSC) activation. Methods …