Rational design and in vivo characterization of mRNA-encoded broadly neutralizing antibody combinations against HIV-1
E Narayanan, S Falcone, SM Elbashir, H Attarwala… - Antibodies, 2022 - mdpi.com
Monoclonal antibodies have been used successfully as recombinant protein therapy;
however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the …
however, for HIV, multiple broadly neutralizing antibodies may be necessary. We used the …
Neutralization breadth and potency of single-chain variable fragments derived from broadly neutralizing antibodies targeting multiple epitopes on the HIV-1 envelope
RT van Dorsten, BE Lambson, CK Wibmer… - Journal of …, 2020 - Am Soc Microbiol
Passive administration of HIV-directed broadly neutralizing antibodies (bNAbs) can prevent
infection in animal models, and human efficacy trials are under way. Single-chain variable …
infection in animal models, and human efficacy trials are under way. Single-chain variable …
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
N Pardi, AJ Secreto, X Shan, F Debonera… - Nature …, 2017 - nature.com
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products,
however, their potential is limited by the high cost of development and manufacturing. Here …
however, their potential is limited by the high cost of development and manufacturing. Here …
Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1
MY Zhang, AR Borges, RG Ptak, Y Wang, AS Dimitrov… - MAbs, 2010 - Taylor & Francis
Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad
neutralizing activity against HIV-1, but there has not been much success in using them as …
neutralizing activity against HIV-1, but there has not been much success in using them as …
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
Several HIV envelope-targeting (Env-targeting) antibodies with broad and potent
neutralizing activity have been identified and shown to have unusual features. Of these, the …
neutralizing activity have been identified and shown to have unusual features. Of these, the …
Candidate antibody-based therapeutics against HIV-1
R Gong, W Chen, DS Dimitrov - BioDrugs, 2012 - Springer
Antibody-based therapeutics have been successfully used for the treatment of various
diseases and as research tools. Several well characterized, broadly neutralizing monoclonal …
diseases and as research tools. Several well characterized, broadly neutralizing monoclonal …
Combinations of single chain variable fragments from HIV broadly neutralizing antibodies demonstrate high potency and breadth
Broadly neutralizing antibodies (bNAbs) are currently being assessed in clinical trials for
their ability to prevent HIV infection. Single chain variable fragments (scFv) of bNAbs have …
their ability to prevent HIV infection. Single chain variable fragments (scFv) of bNAbs have …
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes
The isolation of broadly neutralizing HIV-1 monoclonal antibodies (MAbs) to distinct
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
epitopes on the viral envelope glycoprotein (Env) provides the potential to use combinations …
[HTML][HTML] Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed …
E Gustchina, JM Louis, C Frisch, F Ylera, A Lechner… - Virology, 2009 - Elsevier
Previously we reported a broadly HIV-1 neutralizing mini-antibody (Fab 3674) of modest
potency that was derived from a human non-immune phage library by panning against the …
potency that was derived from a human non-immune phage library by panning against the …
Engineering broadly neutralizing antibodies for HIV prevention and therapy
CK Hua, ME Ackerman - Advanced drug delivery reviews, 2016 - Elsevier
A combination of advances spanning from isolation to delivery of potent HIV-specific
antibodies has begun to revolutionize understandings of antibody-mediated antiviral activity …
antibodies has begun to revolutionize understandings of antibody-mediated antiviral activity …