Among approaches aiming toward functional nervous system restoration, those
implementing microfabrication techniques allow the manufacture of platforms with distinct …

Microfabrication techniques have improved the ability to create platforms where neuronal
cells can be grown and guided to form connections in vitro and in vivo. In particular …

A number of studies have investigated the behavior of neurons on microfabricated
topography for the purpose of developing interfaces for use in neural engineering …

A new generation of in vitro human brain models is vital to surpass the limitations of current
cell culture platforms and animal cell lines in studying brain function and diseases. Brain-on …

Extracellular matrix molecules provide biochemical and topographical cues that influence
cell growth in vivo and in vitro. Effects of topographical cues on hippocampal neuron growth …

Purpose Understanding how surface features influence the establishment and outgrowth of
the axon of developing neurons at the single cell level may aid in designing implantable …

Neurons are sensitive to topographical cues provided either by in vivo or in vitro
environments on the micrometric scale. We have explored the role of randomly distributed …

Surface micropatterns have been widely used as chemical cues to control the
microenvironment of cultured neurons, particularly for neurobiological assays and neurochip …

The challenges in creating cell cultures with controlled topology and in which cells maintain
their in vivo-like phenotype are manifold. Engineering physiologically relevant brain cell …

In this work, nanogroove dimensions as a design input parameter for neuronal differentiation
and neurite outgrowth in brain-on-a-chip (BOC) applications are investigated. Soft …