Studies in genetically tractable organisms such as the nematode Caenorhabditis elegans
have led to pioneering insights into conserved developmental regulatory mechanisms. For …

With the characterization of the Smads 5 years ago, it became possible to trace the TGFβ
signal transduction pathway from the plasma membrane to the nucleus. Since that time …

Transforming growth factor β (TGF-β) and related ligands have potent effects on an
enormous diversity of biological functions in all animals examined. Because of the strong …

Genetic and molecular analysis in Caenorhabditis elegans has produced new insights into
how TGFβ-related pathways transduce signals and the developmental processes in which …

TGF-beta superfamily ligands play fundamental roles in the development and physiology of
diverse animal species. Genetic and genomic analyses in the model organism …

TGF-β signaling in the nematode Caenorhabditis elegans plays multiple roles in the
development of the animal. The Sma/Mab pathway controls body size, male tail sensory ray …

Transforming growth factor-β (TGF-β) signaling is essential for numerous biologic functions.
It is a highly conserved pathway found in all metazoans including the nematode …

Cell-extracellular matrix interactions are crucial for the development of an organism from the
earliest stages of embryogenesis. The main constituents of the extracellular matrix are …

Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell
identity, function, and survival in multicellular animals. Genes encoding five TGF-β family …

C. elegans has played a central role in the elucidation of the TGFβ pathway over the last two
decades. This is due to the high conservation of the pathway components and the power of …