Detecting metal ions in vivo with a high spatiotemporal resolution is critical to understanding
the roles of the metal ions in both healthy and disease states. Although spatiotemporal …

Conspectus With unparalleled programmability, DNA has evolved as a powerful scaffold for
engineering intricate and dynamic systems that can perform diverse tasks. By allowing serial …

DNAzymes have enjoyed success as metal ion sensors outside cells. Their susceptibility to
metal‐dependent cleavage during delivery into cells has limited their intracellular …

Spatial and temporal distributions of metal ions in vitro and in vivo are crucial in our
understanding of the roles of metal ions in biological systems, and yet there is a very limited …

Increasing interest in detecting metal ions in many chemical and biomedical fields has
created demands for developing sensors and imaging agents for metal ions with high …

DNAzyme-based sensors remain at the forefront of metal-ion imaging efforts, but most lack
the subcellular precision necessary to their applications in specific organelles. Here, we …

RNA-cleaving DNAzymes have been demonstrated as a promising platform for sensing
metal ions. However, the poor biological imaging performance of RNA-cleaving DNAzyme …

Construction of probes or nanodevices capable of sensing pH with high spatial and
temporal precision remains a challenge, despite their importance in monitoring of diverse …

The detection of intracellular metal ions is of great importance in understanding metal
homeostasis in cells and related diseases, and yet it remains a significant challenge to …

Highlights•DNAzymes are an emerging class of metal ions sensors with high
selectivity.•Recent progress has been made in using DNAzymes for environmental detection …