Substitution of SERCA2 Cys674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis
L Wang, Z Yang, S Wang, Y Que, X Shu… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose The Cys674 residue (C674) in the sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 (SERCA2) is key to maintaining its enzyme activity. The …
reticulum Ca2+ ATPase 2 (SERCA2) is key to maintaining its enzyme activity. The …
Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm
Y Que, X Shu, L Wang, P Hu, S Wang, R Xiong… - Journal of Molecular and …, 2020 - Elsevier
Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and …
intracellular calcium homeostasis. SERCA2 cysteine 674 (C674) is highly conservative and …
Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ
Y Que, X Shu, L Wang, S Wang, S Li… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which …
reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which …
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts
X Huang, X Lin, L Wang, Y Xie, Y Que, S Li, P Hu… - Biochemical …, 2022 - Elsevier
Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …
[HTML][HTML] Contractile behavior of mouse aorta depends on SERCA2 isoform distribution: effects of replacing SERCA2a by SERCA2b
P Fransen, J Chen, P Vangheluwe, PJ Guns - Frontiers in Physiology, 2020 - frontiersin.org
The Sarco (endo) plasmic reticulum Ca 2+ ATPase (SERCA) actively pumps Ca 2+ into the
sarco/endoplasmic reticulum, thereby regulating intracellular Ca 2+ concentrations and …
sarco/endoplasmic reticulum, thereby regulating intracellular Ca 2+ concentrations and …
Targeting mitochondrial stress with Szeto‐Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress
M Navas‐Madroñal… - British Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Mitochondrial dysfunction and inflammation contribute to
a myriad of cardiovascular diseases. Deleterious crosstalk of mitochondria and persistent …
a myriad of cardiovascular diseases. Deleterious crosstalk of mitochondria and persistent …
[HTML][HTML] SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
Despite advances in cardioprotection, new therapeutic strategies capable of preventing
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …
ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic …
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells
W Yu, Q Zhang, Y Qiu, H Chen, X Huang… - Clinical and …, 2023 - Taylor & Francis
ABSTRACT Background and Purpose Substitution of Cys674 (C674) in the sarcoplasmic/
endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads …
endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads …
[HTML][HTML] Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well …
MD Thompson, Y Mei, RM Weisbrod, M Silver… - Journal of Biological …, 2014 - ASBMB
The sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) is key to Ca 2+ homeostasis and
is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that …
is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that …
Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia-and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage …
Y Mei, MD Thompson, Y Shiraishi, RA Cohen… - Journal of molecular and …, 2014 - Elsevier
Ischemia is a complex phenomenon modulated by the concerted action of several cell types.
We have identified that sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA 2) …
We have identified that sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA 2) …
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